In - House Oral Medications Levothyroxine 100 Mcg Tablet Treat
Product : Levothyroxine Tablets
Specification : 50mcg, 100mcg
Standard : In - house
Packing : 10’s/blister
Levothyroxine is a major hormone derived from the thyroid gland.
Thyroxine is synthesized via the iodination of tyrosines
(monoiodotyrosine) and the coupling of iodotyrosines
(diiodotyrosine) in the thyroglobulin. Thyroxine is released from
thyroglobulin by proteolysis and secreted into the blood. Thyroxine
is peripherally deiodinated to form triiodothyronine which exerts a
broad spectrum of stimulatory effects on cell metabolism.
For use alone or in combination with antithyroid agents to treat
hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema
coma, and stupor.
Levothyroxine (T4) is a synthetically prepared levo isomer of
thyroxine, the major hormone secreted from the thyroid gland.
Thyroxine is released from thyroglobulin by proteolysis and
secreted into the blood. Thyroxine is peripherally deiodinated to
form triiodothyronine (T3) which exerts a broad spectrum of
stimulatory effects on cell metabolism. Thyroid hormone increases
the metabolic rate of cells of all tissues in the body. In the
fetus and newborn, thyroid hormone is important for the growth and
development of all tissues including bones and the brain. In
adults, thyroid hormone helps to maintain brain function, food
metabolism, and body temperature, among other effects. The symptoms
of thyroid deficiency relieved by levothyroxine include slow
speech, lack of energy, weight gain, hair loss, dry thick skin and
unusual sensitivity to cold.
Mechanism of action
Levothyroxine acts like the endogenous thyroid hormone thyroxine
(T4, a tetra-iodinated tyrosine derivative). In the liver and
kidney, T4 is converted to T3, the active metabolite. In order to
increase solubility, the thyroid hormones attach to thyroid hormone
binding proteins, thyroxin-binding globulin, and thyroxin-binding
prealbumin (transthyretin). Transport and binding to thyroid
hormone receptors in the cytoplasm and nucleus then takes place.
Thus by acting as a replacement for natural thyroxine, symptoms of
thyroxine deficiency are relieved.